This anime is based on the game of the same title, a typical dating sim, produced by Aqua PLUS. The story revolves around high school student Kono Takaaki. He spends his high school days one spring with various girls, such as childhood friends Yusuhara Konomi and Kosaka Tamaki, and he encounters various other girls with unique personalities.

The name implies that this is a sequel to "To Heart", but there is no relation between them except that the story of "To Heart 2" takes place two years later at the same school that was featured in "To Heart".