Based on the game

In the year 12,090 A.D technology and the supernatural have overtaken the world. But thanks to the overzealous ambitions of man, the world remains desolate and despotic. What's left of the human race is divided into various towns and cities living in fear of vampires who compose and exist as the Nobility, fending off the monsters and mutants as a result of their existence. On a night five days after the Count Magnus Lee had harmlessly tasted the blood of Doris Lang and chosen her to be his next wife, she hires a vampire hunter by the name of 'D' to rid her of such an ill-gotten fate. As a dhampir (half human, half vampire), there exists a distinct resentment between the hunter and his prey. But as the Count finds out, there is also a peculiar secret behind the past of the Vampire Hunter D.

Continuing his quest to rid the world of the Nobility, the Vampire Hunter D, a dunpeal (half human, half vampire), is summoned by the Elbourne family to rescue their daughter Charlotte from the captivity of Meier Link. The race against time not only involves saving the girl, but also the additional hiring of the Markus Brothers; a volatile and infamous group of Hunters known for their tendency to rid themselves of the competition by any means necessary. To make matters more complicated, when Charlotte is found she is more than reluctant to leave the side of her new love...

Yuki's earliest memory is of a stormy night in winter, wherein she was attacked by a vampire... And then rescued by another. Now 10 years later, Yuki Cross, the adapted daughter of the headmaster of Cross Academy, has grown up and become a guardian of the vampire race, protecting her savior, Kaname, from discovery as he leads a group of vampires at the elite boarding school. But also at her side is Zero Kiryu, a childhood friend who’s hatred for the creatures that destroyed everything he held dear, is now determined never to trust them.

Yuuki wants to know more about her true family and her forgotten past and starts a research. The secret will be revealed. Yuki, Kaname and Zero will show the begining of a new mystery and a forbidden love.

Stranded in the space between human and demon, Miyu was born a vampire and charged with the responsibility of returning evil demons called Shinma to the dark. Being eternally 15, she yearns to return to the dark herself but not until she has banished the Shinma from Earth. And since her awakening, she remains cut off by the facts of who and what she is.

In a universe where men and women are mortal enemies, Hibiki is captured by a band of female pirates. The group find themselves stranded with a super ship they dub the Nirvana and set out for the female home planet. Along the way, they discover the existence of the "The Harvest" and the possible destruction of both men and women.

After the events from the first stage, the female pirates and the men on board the "Nirvana" are heading towards Mejerr to tell them about "The Harvest". But in the way, aside from the new and faster enemies, they find Misty, an earthian girl that will teach to the crew more about their origins, and will give Dita and Hibiki more than an headache

Lucia is an exterminator of Viruses, the demons that eat human souls. When Sumire is pricked by the needle of Lucia's brooch, she obtains a strange power to see demons. Since then, demons attack Sumire, as if they were attracted by her power.

When Yohta is told by the girl he likes, Moemi, that she likes someone else, he rents a video girl tape from a strange video rental shop. When he plays the tape at home, Video Girl Ai emerges from the screen to help him win Moemi's love. But Yohta's VCR had been malfunctioning and now Ai's personality isn't quite what it was designed to be. In the manga, Video Girl the last two out of fifteen volumes involves Video Girl Len in a new story several years after the Video Girl Ai story.